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Review_ArticleReview Article

Laboratory Monitoring of Factor VIII and Factor IX in Hemophilia Patients

Michael A Nardi
American Society for Clinical Laboratory Science October 2019, ascls.118.001305; DOI: https://doi.org/10.29074/ascls.118.001305
Michael A Nardi
New York University of School of Medicine
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  1. Michael A Nardi1
  1. New York University of School of Medicine
  1. ↵* Corresponding author; email: michael.nardi{at}nyumc.org

Abstract

Objective: This review describes and discusses the different types of factors assays used in the clinical laboratory for the diagnosis, as well as during therapeutic management, of hemophilia patients. Background: After diagnosis, infusion of factor replacement concentrates is the standard of treatment for patients with hemophilia to prevent or treat bleeding episodes. Monitoring of the factor activity is necessary to assure proper treatment. Method: This review describes several assays used to assess the factor activity at the time of diagnosis and during therapeutic management. The pros and cons of each assay are discussed in detail. Conclusion: With the introduction of many new replacement products it is important the clinical laboratory understands the advantages and disadvantages of each assay with respects to each of the replacement products available.

  • Hematology
  • Hemostasis
  • Received October 18, 2018.
  • Revision received March 14, 2019.
  • Accepted March 31, 2019.
  • Published by American Society for Clinical Laboratory Science
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American Society for Clinical Laboratory Science: 30 (4)
American Society for Clinical Laboratory Science
Vol. 30, Issue 4
Fall 2017
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Laboratory Monitoring of Factor VIII and Factor IX in Hemophilia Patients
Michael A Nardi
American Society for Clinical Laboratory Science Oct 2019, ascls.118.001305; DOI: 10.29074/ascls.118.001305

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Laboratory Monitoring of Factor VIII and Factor IX in Hemophilia Patients
Michael A Nardi
American Society for Clinical Laboratory Science Oct 2019, ascls.118.001305; DOI: 10.29074/ascls.118.001305
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Keywords

  • Hematology
  • Hemostasis

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