RT Journal Article
SR Electronic
T1 Dialysis Disequilibrium Syndrome: Treatment Leading to Fatality
JF American Society for Clinical Laboratory Science
JO Clin Lab Sci
FD American Society of Chemistry and Laboratory Science
SP 15
OP 18
DO 10.29074/ascls.28.1.15
VO 28
IS 1
A1 Shelbey N. Richey
YR 2015
UL http://hwmaint.clsjournal.ascls.org/content/28/1/15.abstract
AB Dialysis disequilibrium syndrome (DDS) is a rare disorder caused by rapid removal of blood urea nitrogen (BUN) during dialysis treatment resulting in adjusted concentrations of the osmotic gradients between fluid compartments inside the human body. The consequential osmotic pressure may cause rapid cerebral edema, leading to headaches, dizziness, seizures, and in severe circumstances, death. If dialysis is stopped immediately when symptoms appear, DDS will often be self – limiting, and will not cause permanent damage. The best prevention of the syndrome is through gentle reduction of the urea concentration by slowly introducing the hemodialysis in brief, frequent intervals. Primary treatment once the condition has been diagnosed is stabilization of intracranial pressure through the administration of mannitol.ABBREVIATIONS: DDS - dialysis disequilibrium syndrome, BUN - blood urea nitrogen, CSF - cerebrospinal fluid.