TY - JOUR T1 - Sequential Assessment of Troponin in the Diagnosis of Myocardial Infarction JF - American Society for Clinical Laboratory Science JO - Clin Lab Sci SP - 95 LP - 99 DO - 10.29074/ascls.26.2.95 VL - 26 IS - 2 AU - Brandon Edwards AU - Irsha Washington AU - Lester G. Pretlow AU - Gregory Passmore AU - James Dias AU - Scott Wise Y1 - 2013/04/01 UR - http://hwmaint.clsjournal.ascls.org/content/26/2/95.abstract N2 - According to the American Heart Association, cardiovascular disease accounts for more than one third of all deaths in the United States. 1 The purpose of this retrospective case-control study was to determine which sample taken in a sequential draw was most important in diagnosing an acute myocardial infarction (AMI). One-hundred subjects were selected from a convenience sample. The “risk” of AMI diagnosis was modeled using binary multiple logistic regression. Overall, 78% (39 out of 50 cases) were diagnosed with an AMI at Tinitial. Clearly, the initial cTnI assay is the most critical of the four sequential time points for the accurate assessment of the presence or absence of an AMI. Most importantly, sequential troponin testing increased the ability to diagnose AMI by 10-fold.ABBREVIATIONS: ECG - electrocardio-gram, CK - creatine kinase, AMI – acute myocardial infarction, cTnI - cardiac troponin I, CSRA - Central Savannah River Area, STEMI - ST-elevation myocardial infarction ER -