Background: The recently discovered apolipoprotein A5 (ApoA5) is fast gaining attention as
a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model …

<p>Monocrotaline (MCT) is a toxic pyrrolizidine alkaloid of plant origin. Administration of
small doses of MCT or its active metabolite, monocrotaline pyrrole (MCTP), to rats causes …

Neutrophil (PMN) infiltration is an early occurrence in the liver after exposure to hepatotoxic
doses of endotoxin lipopolysaccharide (LPS). The purpose of this study was to test the …

The objective of the current study was to delineate changes that occur in serum analytes
and blood cellular elements in cattle that graze endophyte-infested (Neotyphodium …

Cardiac troponin I is a useful biomarker of myocardial injury, but its use in mice and application
to early drug discovery are not well described. The authors investigated the relationship …

Cardiac troponins (cTns) are established biomarkers of ischemic heart disease in humans.
However, their value as biomarkers of cardiac injury from causes other than ischemic heart …

alpha-Naphthylisothiocyanate (ANIT) causes cholestasis and injury to bile duct epithelium
and hepatic parenchymal cells in rats. The mechanism of toxicity is unknown. Neutrophils (…

Fatty acid binding protein 3 (Fabp3) has been used as a serological biomarker of cardiac
injury, but its utility as a preclinical biomarker of injury to skeletal muscle is not well described. …

Systemic inflammation co-activates coagulation, which unchecked culminates in a lethal
syndrome of multi-organ microvascular thrombosis known as disseminated intravascular …

The safety of pharmaceuticals is typically assessed in the dog and rat prior to investigation
in humans. As a result, a greater understanding of adverse effects in these preclinical testing …