Lipid–Peptide Vesicle Nanoscale Hybrids for Triggered Drug Release by Mild Hyperthermia in Vitro and in Vivo

…, WT Al-Jamal, JV Bossche, TT Bui, AF Drake… - ACS …, 2012 - ACS Publications
The present study describes leucine zipper peptide–lipid hybrid nanoscale vesicles engineered
by self-assembled anchoring of the amphiphilic peptide within the lipid bilayer. These …

Fate of silica nanoparticles in simulated primary wastewater treatment

…, MJ Bowes, MJ Lawrence, AF Drake… - Environmental …, 2009 - ACS Publications
Through novel application of small-angle neutron scattering, we examined the fate of silica
nanoparticles (SiO 2 NPs) during simulated primary wastewater treatment, by measuring, in …

The importance of extended conformations and, in particular, the PII conformation for the molecular recognition of peptides

G Siligardi, AF Drake - Biopolymers: Original Research on …, 1995 - Wiley Online Library
Crystallographic, isotopic labeling nmr and transferred nuclear Overhauser effect studies have
highlighted the extended conformation as a very important element of secondary structure …

Reassessment of the electronic circular dichroism criteria for random coil conformations of poly (L-lysine) and the implications for protein folding and denaturation …

AF Drake, G Siligardi, WA Gibbons - Biophysical chemistry, 1988 - Elsevier
The circular dichroism (CD) spectra of poly(l-lysine) in water and ethanediol/water (2:1)
solutions in the temperature range − 110 to 85C are presented. The results combined with …

Enzymatically cross-linked tilapia gelatin hydrogels: physical, chemical, and hybrid networks

F Bode, MA Da Silva, AF Drake… - …, 2011 - ACS Publications
This Article investigates different types of networks formed from tilapia fish gelatin (10% w/w)
in the presence and absence of the enzymatic cross-linker microbial transglutaminase. The …

Polarisation modulation-the measurement of linear and circular dichroism

AF Drake - Journal of Physics E: Scientific Instruments, 1986 - iopscience.iop.org
Dichroism is usually measured using two separate polarisation spectra. However, when the
difference in the transmission of oppositely polarised light is very small, the superior method …

Characterization of protein aggregation: the case of a therapeutic immunoglobulin

B Demeule, MJ Lawrence, AF Drake, R Gurny… - … et Biophysica Acta (BBA …, 2007 - Elsevier
In this paper, a therapeutic immunoglobulin (Antibody A) has been characterized in two
solutions: (1) 0.1% acetic acid containing 50 mM magnesium chloride, a solution in which the …

Amyloid β-peptide 25–35 self-assembly and its inhibition: A model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease …

M Naldi, J Fiori, M Pistolozzi, AF Drake… - ACS chemical …, 2012 - ACS Publications
Combined results of theoretical molecular dynamic simulations and in vitro spectroscopic (circular
dichroism and fluorescence) studies are presented, providing the atomistic and …

[HTML][HTML] Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic α-helical peptides

…, RA Atkinson, JKW Lam, SS Bansal, AF Drake… - Journal of Biological …, 2012 - ASBMB
We used a combination of fluorescence, circular dichroism (CD), and NMR spectroscopies in
conjunction with size exclusion chromatography to help rationalize the relative antibacterial…

[HTML][HTML] Undervalued and ignored: Are humans poorly adapted to energy-dense foods?

JM Brunstrom, ACL Drake, CG Forde, PJ Rogers - Appetite, 2018 - Elsevier
In many species the capacity to accurately differentiate the energy density (kcal/g) of foods
is critical because it greatly improves efficiency in foraging. In modern humans this ability …