Many intracellular pathogens infect a broad range of host tissues, but the importance of T
cells for immunity in these sites is unclear because most of our understanding of antimicrobial …

Memory T cells can be divided into central memory T cell (T CM cell) and effector memory T
cell (T EM cell) subsets based on homing characteristics and effector functions. Whether T …

Cross-presentation of cell-bound Ags from established, solid tumors to CD8 cells is efficient
and likely to have a role in determining host response to tumor. A number of investigators …

A number of tumor studies have indicated a link between CD4 help and the magnitude and
persistence of CTL activity; however, the mechanisms underlying this have been largely …

Memory T cells are distributed throughout the body following infection, but the migratory
dynamics of the memory pool in vivo is unknown. The ability of circulating microbe-specific …

The intestinal mucosal CD8 T cell response to infection with Listeria monocytogenes was
measured using MHC class I tetramers and was compared with the response in peripheral …

Following activation within secondary lymphoid tissue, CD8 T cells must migrate to targets,
such as infected self tissue, allografts, and tumors, to mediate contact-dependent effector …

Tumor growth is rarely associated with a strong specific CTL response, suggesting that the
immune system is ignorant of the presence of tumor because the Ags are not readily …

Reprogramming the tumor microenvironment to increase immune-mediated responses is
currently of intense interest. Patients with immune-infiltrated “hot” tumors demonstrate higher …

The role of tumor-specific CD8 and CD4 lymphocytes in rejecting solid tumors has been
difficult to determine because of the lack of models in which tumor antigen, specific CD8 cells, …