Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin
…, AA Sarafandi, AM Kelaher… - The Journal of …, 2003 - academic.oup.com
Invasive pulmonary aspergillosis is an important cause of morbidity and mortality in
immunocompromised patients. Simultaneous inhibition of fungal cell-wall and cell-membrane …
immunocompromised patients. Simultaneous inhibition of fungal cell-wall and cell-membrane …
The Pharmacokinetics and Pharmacodynamics of Micafungin in Experimental Hematogenous Candida Meningoencephalitis: Implications for Echinocandin Therapy …
…, V Petraitis, R Petraitiene, AM Kelaher… - The Journal of …, 2008 - academic.oup.com
Background. Hematogenous Candida meningoencephalitis (HCME) is a relatively frequent
manifestation of disseminated candidiasis in neonates and is associated with significant …
manifestation of disseminated candidiasis in neonates and is associated with significant …
Pathogenesis of Aspergillus fumigatus and the Kinetics of Galactomannan in an In Vitro Model of Early Invasive Pulmonary Aspergillosis: Implications for Antifungal …
…, D Mickiene, T Sein, J Peter, AM Kelaher… - The Journal of …, 2007 - academic.oup.com
Background. Little is known about the pathogenesis of invasive pulmonary aspergillosis and
the relationship between the kinetics of diagnostic markers and the outcome of antifungal …
the relationship between the kinetics of diagnostic markers and the outcome of antifungal …
Detection of galactomannan antigenemia in patients receiving piperacillin-tazobactam and correlations between in vitro, in vivo, and clinical properties of the drug …
…, T Sein, R Schaufele, A Kelaher… - Journal of clinical …, 2004 - Am Soc Microbiol
Recent case reports describe patients receiving piperacillin-tazobactam who were found to
have circulating galactomannan detected by the double sandwich enzyme-linked …
have circulating galactomannan detected by the double sandwich enzyme-linked …
Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: in vitro and in vivo correlation
…, P Lin, T Stergiopoulou, AM Kelaher… - The Journal of …, 2006 - academic.oup.com
Combination antifungal therapy is increasingly used in the treatment of invasive aspergillosis.
Whether the interaction between amphotericin B and triazoles is antagonistic against …
Whether the interaction between amphotericin B and triazoles is antagonistic against …
Characterization and Comparison of Galactomannan Enzyme Immunoassay and Quantitative Real-Time PCR Assay for Detection of Aspergillus fumigatus in …
…, R Petraitiene, V Petraitis, AM Kelaher… - Journal of clinical …, 2006 - Am Soc Microbiol
Bronchoalveolar lavage (BAL) is widely used for evaluation of patients with suspected invasive
pulmonary aspergillosis (IPA). However, the diagnostic yield of BAL for detection of IPA …
pulmonary aspergillosis (IPA). However, the diagnostic yield of BAL for detection of IPA …
Cerebrospinal fluid and plasma (1→ 3)-β-D-glucan as surrogate markers for detection and monitoring of therapeutic response in experimental hematogenous …
…, WW Hope, D Mickiene, AM Kelaher… - Antimicrobial agents …, 2008 - Am Soc Microbiol
The treatment, diagnosis and therapeutic monitoring of hematogenous Candida
meningoencephalitis (HCME) are not well understood. We therefore studied the expression of …
meningoencephalitis (HCME) are not well understood. We therefore studied the expression of …
Development and validation of a quantitative real-time PCR assay using fluorescence resonance energy transfer technology for detection of Aspergillus fumigatus in …
…, V Petraitis, R Petraitiene, AM Kelaher… - Journal of clinical …, 2003 - Am Soc Microbiol
Invasive pulmonary aspergillosis (IPA) is a frequently fatal infection in immunocompromised
patients that is difficult to diagnose. Present methods for detection of Aspergillus spp. in …
patients that is difficult to diagnose. Present methods for detection of Aspergillus spp. in …
Use of Quantitative Real-Time PCR To Study the Kinetics of Extracellular DNA Released from Candida albicans, with Implications for Diagnosis of Invasive …
…, R Petraitiene, V Petraitis, AM Kelaher… - Journal of clinical …, 2006 - Am Soc Microbiol
Quantitative real-time PCR (qPCR) is considered one of the most sensitive methods to detect
low levels of DNA from pathogens in clinical samples. To improve the design of qPCR for …
low levels of DNA from pathogens in clinical samples. To improve the design of qPCR for …
Efficacy, Plasma Pharmacokinetics, and Safety of Icofungipen, an Inhibitor of Candida Isoleucyl-tRNA Synthetase, in Treatment of Experimental Disseminated …
R Petraitiene, V Petraitis, AM Kelaher… - Antimicrobial agents …, 2005 - Am Soc Microbiol
Icofungipen (formerly PLD-118) is a synthetic derivative of the naturally occurring β-amino
acid cispentacin that blocks isoleucyl-tRNA synthetase, resulting in the inhibition of protein …
acid cispentacin that blocks isoleucyl-tRNA synthetase, resulting in the inhibition of protein …
