Colorectal tumorigenesis proceeds through an accumulation of specific genetic alterations.
Studies of the mechanism by which these genetic changes effect malignant transformation …

BCR-ABL expression is presumed to effect clonal expansion in chronic myeloid leukemia (CML)
by deregulation of cell proliferation. However, most studies have found that relative …

We direct your readers' attention to the principles and guidelines (Supplementary Guidelines)
developed by the Next-generation Sequencing: Standardization of Clinical Testing (Nex-…

Caspases mediate essential key proteolytic events in inflammatory cascades and the apoptotic
cell death pathway. Human caspases functionally segregate into two distinct subfamilies: …

Questions of reproducibility and efficacy of histologic malignancy grading relative to
alternative proliferation index measurements for outcome prediction remain unanswered. …

Recent evidence has implicated germ-line mutations of the p53 gene as the cause of cancer
susceptibility in the Li-Fraumeni syndrome, associated with the development of breast …

Loss-of-function defects in DNA mismatch repair (MMR), which manifest as high levels of
microsatellite instability (MSI), occur in approximately 15% of all colorectal carcinomas (CRCs). …

A variety of neutral serine proteases are important for the effector functions of immune cells.
The neutrophil-derived serine proteases cathepsin G and neutrophil elastase are implicated …

The classical definition of lymphohematopoietic stem cells (LHSC), the most primitive progenitors
of all blood cells, requires that they have the capacity for self-renewal and for the long-…

The possibility that umbilical cord and placental blood from an HLA- identical sibling might
produce stable donor-derived lymphohematopoietic engraftment was tested in a patient with …