Introduction Internet addiction disorder (IAD) is characterized by the problematic use of online
video games, computer use, and mobile handheld devices. While not officially a clinical …

OBJECTIVE: To assess survival of methicillin-resistant Staphylococcus aureus (MRSA) on
fomites encountered by health students. DESIGN: Three suspensions of MRSA were made to …

Excessive use of video games may be associated with sleep deprivation, resulting in poor
job performance and atypical mood disorders. Three active duty service members in the US …

Objectives: Tacrolimus (FK506) is an immunosuppressive drug with great clinical promise.
There is a controversy regarding the role of tacrolimus metabolites in immunosuppression …

We have identified an 8.4 kDa minor immunophilin from calf thymus and Jurkat T cells as
ubiquitin. It binds tacrolimus and sirolimus with K d 's of 0.8 and 0.08 nM, respectively. The …

The intracellular class of proteins that bind the interleukin-2 suppressing drugs (cyclosporin,
tacrolimus, and sirolimus) are called immunophilins. It is believed that the drugs do not act …

OBJECTIVE: This review examines the performance of 4 assays for sirolimus in terms of
their ability to meet 6 guidelines determined by a panel of experts. BACKGROUND: Four …

Objectives: We have previously identified a minor immunophilin of 52 kDa molecular weight
capable of binding tacrolimus and sirolimus. Because immunophilins are capable of binding …

Objectives: We have previously identified three minor immunophilins of molecular weights
37 kDa, 14 kDa, and 5–8 kDa capable of binding tacrolimus and sirolimus. Design and …

Objective: We present biochemical characterization of the previously described 14 kDa, 37
kDa, and 52 kDa immunophilins and a newly identified 5–8 kDa immunophilin. Design and …