User profiles for Jason Christiansen
Jason ChristiansenEpic Sciences Verified email at boundlessbio.com Cited by 6194 |
Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis
JJ Christiansen, AK Rajasekaran - Cancer research, 2006 - AACR
For most carcinomas, progression toward malignancy is accompanied by loss of epithelial
differentiation and a shift towards a mesenchymal phenotype. This process, referred to as …
differentiation and a shift towards a mesenchymal phenotype. This process, referred to as …
[HTML][HTML] Acquired Resistance to KRASG12C Inhibition in Cancer
…, BM Wolpin, J Wiese, J Christiansen… - … England Journal of …, 2021 - Mass Medical Soc
Background Clinical trials of the KRAS inhibitors adagrasib and sotorasib have shown
promising activity in cancers harboring KRAS glycine-to-cysteine amino acid substitutions at …
promising activity in cancers harboring KRAS glycine-to-cysteine amino acid substitutions at …
Safety and antitumor activity of the multitargeted pan-TRK, ROS1, and ALK inhibitor entrectinib: combined results from two phase I trials (ALKA-372-001 and …
…, S Damian, M Duca, E Ardini, G Li, J Christiansen… - Cancer discovery, 2017 - AACR
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was
evaluated in two phase I studies in patients with advanced or metastatic solid tumors, including …
evaluated in two phase I studies in patients with advanced or metastatic solid tumors, including …
Multiplexed protein profiling on microarrays by rolling-circle amplification
…, I Laroche, Z Zhou, VT Tchernev, J Christiansen… - Nature …, 2002 - nature.com
Fluorescent-sandwich immunoassays on microarrays hold appeal for proteomics studies,
because equipment and antibodies are readily available, and assays are simple, scalable, …
because equipment and antibodies are readily available, and assays are simple, scalable, …
Is prostate-specific membrane antigen a multifunctional protein?
…, G Anilkumar, JJ Christiansen - American Journal of …, 2005 - journals.physiology.org
Prostate-specific membrane antigen (PSMA) is a metallopeptidase expressed predominantly
in prostate cancer (PCa) cells. PSMA is considered a biomarker for PCa and is under …
in prostate cancer (PCa) cells. PSMA is considered a biomarker for PCa and is under …
Catalytic and Biophysical Properties of a Nitrogenase Apo-MoFe Protein Produced by a nifB-Deletion Mutant of Azotobacter vinelandii
J Christiansen, PJ Goodwin, WN Lanzilotta… - Biochemistry, 1998 - ACS Publications
A Zn-immobilized metal-affinity chromatography technique was used to purify a poly-histidine-tagged,
FeMo-cofactorless MoFe protein (apo-MoFe protein) from a nifB-deletion mutant of …
FeMo-cofactorless MoFe protein (apo-MoFe protein) from a nifB-deletion mutant of …
ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer
…, JF Hechtman, J Christiansen… - Journal of the …, 2017 - academic.oup.com
Background ALK, ROS1, and NTRK fusions occur in 0.2% to 2.4% of colorectal cancers.
Pioneer cases of metastatic colorectal cancer (mCRC) patients bearing rearrangements who …
Pioneer cases of metastatic colorectal cancer (mCRC) patients bearing rearrangements who …
Molecular profiling of mammary analog secretory carcinoma revealed a subset of tumors harboring a novel ETV6-RET translocation: report of 10 cases
…, J Pavelka, SJ Potts, J Christiansen… - The American journal …, 2018 - journals.lww.com
ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of
ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological …
ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological …
RTOG 0211: a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients
…, A Choucair, M Dolled-Filhart, J Christiansen… - International Journal of …, 2013 - Elsevier
PURPOSE: To determine the safety and efficacy of gefitinib, an epidermal growth factor
receptor (EGFR) tyrosine kinase inhibitor, in combination with radiation for newly diagnosed …
receptor (EGFR) tyrosine kinase inhibitor, in combination with radiation for newly diagnosed …
Biological impediments to monoclonal antibody–based cancer immunotherapy
J Christiansen, AK Rajasekaran - Molecular cancer therapeutics, 2004 - AACR
The ability of antibodies to exploit antigenic differences between normal and malignant
tissues and to exact a variety of antitumor responses offers significant advantages to …
tissues and to exact a variety of antitumor responses offers significant advantages to …