A role for PrP in the toxic effect of oligomeric forms of Aβ, implicated in Alzheimer's disease (AD),
has been suggested but remains controversial. Here we show that PrP is required for …

The molecular pathways leading to Alzheimer-type dementia are not well understood, but
the amyloid β-protein is believed to be centrally involved. The quantity of amyloid β-protein …

Synthetic amyloid-β protein (Aβ) oligomers bind with high affinity to cellular prion protein (PrP
C ), but the role of this interaction in mediating the disruption of synaptic plasticity by such …

Alzheimer's disease (AD) is the most common form of dementia and associated with progressive
deposition of amyloid β‐peptides (Aβ) in the brain. Aβ derives by sequential proteolytic …

Aggregation of the amyloid β-protein (Aβ) is believed to play a central role in initiating the
molecular cascade that culminates in Alzheimer-type dementia (AD), a disease which in its …

The review of turnover of ongoing case managers in the private agencies providing foster
care and safety services for the Bureau of Milwaukee Child Welfare (BMCW) revealed that …

Background Sexual health is one of the key dimensions of health across all ages. Understanding
risky sexual behaviors remains an important area of public health research. This study …

Recent data suggest that soluble, non-fibrillar assemblies of the amyloid β-protein (Aβ) may
mediate the synaptic deficits that characterize the early stages of Alzheimer’s disease. …

Somatic hypermutation (SH) generates point mutations within rearranged immunoglobulin (Ig)
genes of activated B cells, providing genetic diversity for the affinity maturation of …

Although plaques composed of the amyloid β-protein (Aβ) are considered a defining feature
of Alzheimer's disease (AD), they are also found in cognitively normal individuals and …