The Ink4/Arf locus encodes two tumour-suppressor proteins, p16 Ink4a and p19 Arf, that
govern the antiproliferative functions of the retinoblastoma and p53 proteins, respectively. Here …

Rac and Rho GTPases function as critical regulators of actin cytoskeleton remodelling during
cell spreading and migration. Here we demonstrate that Rac-mediated reactive oxygen …

This study investigated whether soluble paracrine factors mediated Salmonella-induced IL-8
expression in polarized model intestinal epithelia. We found that the basolateral media of …

THEprotein encoded by the retinoblastoma susceptibility gene (Rb) functions as a tumour
suppressor and negative growth regulator 1 . As actively growing cells require the ongoing …

Mammalian cells contain three closely related ras genes, H-ras, K-ras and N-ras. Although
in a given tumour type, oncogenic mutations are selectively observed in only one of the ras …

Ras proteins play a central role in transducing signals that control cell proliferation,
differentiation, motility, and survival. The location-specific signaling activity of Ras has been …

Ligand-induced activation of the epidermal growth factor receptor (EGFR) initiates multiple
signal-transduction pathways as well as trafficking events that relocalize the receptors from …

The adenovirus type 5 (Ad5) E4-6/7 protein interacts directly with different members of the
E2F family and mediates the cooperative and stable binding of E2F to a unique pair of binding …

7-Methylguanosine (m 7 G), also known as the mRNA “cap”, is used as a molecular tag in
eukaryotic cells to mark the 5‘ end of messenger RNAs. The mRNA cap is required for several …

Purpose Retinitis pigmentosa (RP) associated with biallelic variants in CDHR1 has rarely
been reported, and detailed phenotyping data are not available. RP implies relative …