The synthesis and SAR studies of a novel N-aryl pyridinone class of p38 kinase inhibitors are
described. Systematic structural modifications to the HTS lead, 5, led to the identification of …

A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols
is described which potently and reversibly inhibit cholesteryl …

… 4 Reported here are some of our related studies in which we demonstrate that various 1,m-alkenols
(m = 2-4; ie, allylic, homoallylic, and bishomoallylic) can be either self- or cross-…

The identification and evolution of a series of potent and selective p38 inhibitors is described.
p38 inhibitors based on a N-benzyl pyridinone high-throughput screening hit were …

Despite their long history, dioxenium cations are underutilized reactive synthetic intermediates.
It was found that ortho esters andhomoallylic alcohols in the presence of Lewis acids …

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A series of N-aryl pyridinone inhibitors of p38 mitogen activated protein (MAP) kinase were
designed and prepared based on the screening hit SC-25028 (1) and structural comparisons …

The utilization of 3-methyl-4H-[1,2,4]-oxadiazol-5-one as a versatile protected acetamidine is
demonstrated through employment in a variety of synthetic sequences. The potassium salt (…

… m-coupon sharing not only provides promotion information to receivers but can also generate
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