… derived from those described (Henderson et al., 1986}. The image data from the untilted
and slightly tilted specimens used in the earlier projection analyses (Henderson et al., 1986; …

A 7-Å resolution map of the purple membrane has been obtained by electron microscopy of
tilted, unstained specimens. The protein in the membrane contains seven, closely packed, α-…

A computational procedure is described for assigning the absolute hand of the structure of a
protein or assembly determined by single-particle electron microscopy. The procedure …

G-protein-coupled receptors have a major role in transmembrane signalling in most eukaryotes
and many are important drug targets. Here we report the 2.7 Å resolution crystal structure …

The projected structures of two unstained periodic biological specimens, the purple membrane
and catalase, have been determined by electron microscopy to resolutions of 7 Å and 9 Å…

Radiation damage is the main problem which prevents the determination of the structure of
a single biological macromolecule at atomic resolution using any kind of microscopy. This is …

Solvents make a large contribution to the environmental impact of manufacturing processes
of active pharmaceutical ingredients (API), as well as playing an important role in other …

Using electron diffraction data corrected for diffuse scattering together with additional phase
information from 30 new images of tilted specimens, an improved experimental density map …

LIGHT absorption by the visual pigment rhodopsin 1,2 triggers, through G-protein coupling,
a cascade of events in the outer segment of the rod cell of the vertebrate retina that results in …

GlaxoSmithKline (GSK) has previously reported on the development of a GSK solvent guide,
the incorporation of lifecycle impact and the expansion of the guide including a …