The mode of action of vitamin K: identification of γ-carboxyglutamic acid as a component of prothrombin
GL Nelsestuen, TH Zytkovicz, JB Howard - Journal of Biological Chemistry, 1974 - ASBMB
An unusual tryptic peptide isolated from the protein, prothrombin, has recently been shown
to contain at least a portion of the vitamin K-dependent region of this protein (Nelsestuen, GL, …
to contain at least a portion of the vitamin K-dependent region of this protein (Nelsestuen, GL, …
Tandem mass spectrometric analysis for amino, organic, and fatty acid disorders in newborn dried blood spots: a two-year summary from the New England Newborn …
TH Zytkovicz, EF Fitzgerald, D Marsden… - Clinical …, 2001 - academic.oup.com
Background: Tandem mass spectrometry (MS/MS) is rapidly being adopted by newborn
screening programs to screen dried blood spots for >20 markers of disease in a single assay. …
screening programs to screen dried blood spots for >20 markers of disease in a single assay. …
Newborn screening for hepatorenal tyrosinemia by tandem mass spectrometry: analysis of succinylacetone extracted from dried blood spots
P Allard, A Grenier, MS Korson, TH Zytkovicz - Clinical biochemistry, 2004 - Elsevier
OBJECTIVES: To develop a method for the determination of succinylacetone (SA) in dried
blood spots (DBS) using tandem mass spectrometry (MS/MS). METHODS: SA was extracted …
blood spots (DBS) using tandem mass spectrometry (MS/MS). METHODS: SA was extracted …
Spectrum of medium-chain acyl-CoA dehydrogenase deficiency detected by newborn screening
HW Hsu, TH Zytkovicz, AM Comeau, AW Strauss… - …, 2008 - publications.aap.org
OBJECTIVE. Our goal was to describe the clinical spectrum of medium-chain acyl-CoA
dehydrogenase deficiency detected by routine newborn screening and assess factors associated …
dehydrogenase deficiency detected by routine newborn screening and assess factors associated …
Determination of phenylalanine and tyrosine in dried blood specimens by ion-exchange chromatography using the Hitachi L-8800 analyzer
P Allard, LD Cowell, TH Zytkovicz, MS Korson… - Clinical …, 2004 - Elsevier
Objectives: The treatment for phenylketonuria (PKU) includes monitoring blood phenylalanine
(Phe) levels on a regular basis. To reduce inconvenience to the patient and family, blood …
(Phe) levels on a regular basis. To reduce inconvenience to the patient and family, blood …
[HTML][HTML] [3H] diborane reduction of vitamin K-dependent calcium-binding proteins. Identification of a unique amino acid.
TH Zytkovicz, GL Nelsestuen - Journal of Biological Chemistry, 1975 - Elsevier
gamma-Carboxyglutamic acid has recently been identified as a component of the vitamin K-dependent
region of bovine prothrombin (Nelsestuen, GL, Zytkovicz, TH, and Howard JB (…
region of bovine prothrombin (Nelsestuen, GL, Zytkovicz, TH, and Howard JB (…
On the role of γ-carboxyglutamic acid in calcium and phospholipid binding
GL Nelsestuen, M Broderius, TH Zytkovicz… - Biochemical and …, 1975 - Elsevier
The vitamin K-dependent amino acid, γ-carboxyglutamic acid, is essential for calcium binding
by prothrombin and blood clotting factor X. The studies reported here demonstrate that …
by prothrombin and blood clotting factor X. The studies reported here demonstrate that …
Newborn screening for glutaric aciduria-II: The new england experience
…, C Phornphutkul, DA Sweetser, TH Zytkovicz… - JIMD Reports-Case and …, 2014 - Springer
Newborn screening (NBS) using tandem mass spectrometry (MS/MS) permits detection of
neonates with Glutaric Aciduria-Type II (GA-II). We report follow-up of positive GA-II screens by …
neonates with Glutaric Aciduria-Type II (GA-II). We report follow-up of positive GA-II screens by …
Newborn screening for hepatorenal tyrosinemia-I by tandem mass spectrometry using pooled samples: a four-year summary by the New England newborn screening …
TH Zytkovicz, I Sahai, A Rush, A Odewale… - Clinical …, 2013 - Elsevier
OBJECTIVE: The objective of this study is to develop an isotope dilution liquid chromatography
tandem mass spectrometry assay to screen for hepatorenal tyrosinemia (HT) from …
tandem mass spectrometry assay to screen for hepatorenal tyrosinemia (HT) from …
Identification and Characterization of a High-Affinity Saturable Binding Protein for the Carcinogen Benzo(a)pyrene
TH Zytkovicz - Cancer Research, 1982 - AACR
A protein that binds the chemical carcinogen, benzo(a)pyrene (BP), in a high-affinity and
saturable manner has been identified in cell extracts from the AKR-2B mouse embryo cell line. …
saturable manner has been identified in cell extracts from the AKR-2B mouse embryo cell line. …