Blood lymphocyte numbers, essential for the development of efficient immune responses, are
maintained by recirculation through secondary lymphoid organs. We show that lymphocyte …

Anemia continues to be a major global health problem and the World Health Organization (WHO)
estimates that about two billion people (25% of world’s population) have some form of …

… Springer, Mary Jo Staruch, William H. Parsons, Kathleen M. Rupprecht. Potent Kv1.3
inhibitors from correolide—modification of the C18 position. Bioorganic & Medicinal Chemistry …

The voltage-gated potassium channel, K v 1.3, is a novel target for development of
immunosuppressants. Using a functional 86 Rb + efflux assay, a new class of high-affinity K v 1.3 …

… Annonaceous acetogenins have been previously reported (Rupprecht et al. 1986, Alkofahi
… 1), a major bioactive component of a complex mixture of these compounds (Rupprecht et al. …

The voltage-gated potassium channel, Kv1.3, is specifically expressed on human lymphocytes,
where it controls membrane potential and calcium influx. Blockade of Kv1.3 channels by …

Substantial strides have been made in the past decade in the discovery of potent
immunosuppressants that are effective in the prevention of rejection in organ transplantation and in …

The voltage-gated potassium channel, Kv1.3, is present in human T-lymphocytes. Blockade
of Kv1.3 results in T-cell depolarization, inhibition of T-cell activation, and attenuation of …

… For these experiments, we investigated homo-multimeric K v 1.2 and K v 1.5 channels stably
expressed in HEK293 cells. Binding of [ 3 H]-trans-NPCO-DSC to membranes derived from …

Screening of crude extracts of the bark of Annona hullata showed cytotoxic and pesticidal
activities. By monitoring with brine-shrimp lethality, two novel, extremely po-tent acetogenins, …