Human myeloid leukemias provide models of maturation arrest and differentiation therapy of
cancer. The genetic lesions of leukemia result in a block of differentiation (maturation arrest) …

Alkaline phosphatase (ALP) is a significant biomarker in clinical diagnostics, and the
abnormal level of ALP enzyme in serum is closely related to various diseases such as bone …

Cancers arise from stem cells in adult tissues and the cells that make up a cancer reflect the
same stem cell→ progeny→ differentiation progression observed in normal tissues. All adult …

A multicolor and photothermal dual-mode assay for sensitive alkaline phosphatase (ALP)
determination was realized based on the 3, 3′, 5, 5′-tetramethylbenzidine (TMB)-induced …

Protein tyrosine kinases are key biochemical effectors of the signaling pathways that drive
both normal and aberrant cell behavior. The ability to visualize the activity of tyrosine …

Chromosomal rearrangements occur frequently in humans and can be disease-associated
or phenotypically neutral. Recent technological advances have led to the discovery of copy …

Abstract Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder distinguished by
a specific genetic anomaly known as a reciprocal translocation between chromosomes 9 …

To be maximally effective, therapy of cancer must be directed against both the resting stem
cells and the proliferating cells of the cancer. The cell populations of both normal and cancer …

The Ultrastructure of Human Tumours: Applications in Diagnosis and Research describes
the core features as seen by transmission electron microscopy, defining the different types of …

Philadelphia (Ph) chromosome‐positive leukemia is characterized by the BCR/ABL1 fusion
protein that affects a wide range of signal transduction pathways. The knowledge about its …