Black pepper and health claims: a comprehensive treatise

MS Butt, I Pasha, MT Sultan… - Critical reviews in …, 2013 - Taylor & Francis
For millennia, spices have been an integral part of human diets and commerce. Recently,
the widespread recognition of diet-health linkages bolsters their dietary importance. The …

[HTML][HTML] Antitumor potential of immunomodulatory natural products

G Nuzzo, G Senese, C Gallo, F Albiani, L Romano… - Marine Drugs, 2022 - mdpi.com
Cancer is one of the leading causes of death globally. Anticancer drugs aim to block tumor
growth by killing cancerous cells in order to prevent tumor progression and metastasis …

Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress

PB Yaffe, MR Power Coombs… - Molecular …, 2015 - Wiley Online Library
Piperine, a piperidine alkaloid present in black pepper, inhibits the growth of cancer cells,
although the mechanism of action is not well understood. In this study, we show that piperine …

[HTML][HTML] Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

R Subramani, E Gonzalez, A Arumugam, S Nandy… - Scientific reports, 2016 - nature.com
The mortality and morbidity rates of pancreatic cancer are high because of its extremely
invasive and metastatic nature. Its lack of symptoms, late diagnosis and chemo–resistance …

In Vitro Investigation of the Potential Immunomodulatory and Anti-Cancer Activities of Black Pepper (Piper nigrum) and Cardamom (Elettaria cardamomum)

AF Majdalawieh, RI Carr - Journal of Medicinal Food, 2010 - liebertpub.com
Although the immunomodulatory effects of many herbs have been extensively studied,
research related to possible immunomodulatory effects of various spices is relatively scarce …

Pro-oxidant natural products as anticancer agents

C Martin-Cordero, A Jose Leon-Gonzalez… - Current drug …, 2012 - ingentaconnect.com
Cancer cells produce high levels of reactive oxygen species (ROS) that lead to a state of
increased basal oxidative stress. Since this state of oxidative stress makes cancer cells …

[HTML][HTML] Resveratrol from dietary supplement to a drug candidate: An assessment of potential

S Khattar, SA Khan, SAA Zaidi, M Darvishikolour… - Pharmaceuticals, 2022 - mdpi.com
Resveratrol (RVT) is a well known phyto-chemical and is widely used in dietary supplements
and botanical products. It shows a wide range of pharmacological/beneficial effects …

[HTML][HTML] Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine

E Turrini, P Sestili, C Fimognari - Toxins, 2020 - mdpi.com
The main limits of current anticancer therapy are relapses, chemoresistance, and toxic
effects resulting from its poor selectivity towards cancer cells that severely impair a patient's …

[HTML][HTML] Piperine, a bioactive component of pepper spice exerts therapeutic effects on androgen dependent and androgen independent prostate cancer cells

A Samykutty, AV Shetty, G Dakshinamoorthy… - PLoS …, 2013 - journals.plos.org
Prostate cancer is the most common solid malignancy in men, with 32,000 deaths annually.
Piperine, a major alkaloid constituent of black pepper, has previously been reported to have …

[HTML][HTML] Curcumin sensitizes silymarin to exert synergistic anticancer activity in colon cancer cells

A Montgomery, T Adeyeni, KK San, RM Heuertz… - Journal of …, 2016 - ncbi.nlm.nih.gov
We studied combinatorial interactions of two phytochemicals, curcumin and silymarin, in
their action against cancer cell proliferation. Curcumin is the major component of the spice …