There have been significant changes in the diagnosis and definition of acute myocardial
infarction over the years. From its first description and definition over 150 years ago to the …

ABSTRACT In the United States, heart disease is the leading cause of death and accounts
for one in every four deaths each year. Coronary artery disease (CAD) is the most common …

The development and ongoing implementation of the high-sensitivity cardiac troponin
assays has generated considerable interest. Increased sensitivity offers opportunities for …

Cardiac troponin is the biomarker of choice for the diagnosis of acute myocardial infarction.
Recent consensus recommendations have adopted a concentration of troponin above the …

In the not too distant future, high-sensitivity cardiac troponin assays will be introduced for
use in the United States. They bring with them many exciting new opportunities within …

Cardiac troponin assays have an established and undisputed role in the diagnosis and risk
stratification of patients with acute myocardial infarction. As troponin assays gets more …

The discussion focused primarily on (1) chemical markers of myocardial damage,(2)
educating physicians on the impact of more positive troponin results due to high sensitivity …

Under normal circumstances, most intracellular troponin is part of the muscle contractile
apparatus, and only a small percentage (< 2–8%) is free in the cytoplasm. The presence of a …

Acute coronary syndrome (CHD) represents a major cause of morbidity and mortality,
accounting for more than 8 millions deaths in 2013 worldwide [1]. Nevertheless, the mortality …

by Allan S. Jaffe, MD, Cardiovascular Division, Washington University School of Medicine,
St. Louis, Missouri ma he practice of modem day cardiology demands more rapid, more …