Pathogen reduction in platelets: A review of the proposed draft guidance

J Tracy - American Society for Clinical Laboratory Science, 2017 - clsjournal.ascls.org
In an effort to reduce the incidence of transfusion-transmitted infections (TTI) and septic
transfusion reactions (STR) from bacterially-contaminated platelet products, the Center for …

Evaluation of bacterial safety approaches of platelet blood concentrates: bacterial screening and pathogen reduction

MR Rezvany, A Moradi Hasan-Abad… - Frontiers in Medicine - frontiersin.org
This mini-review analyzed two approaches to screening bacterial contamination and
utilizing pathogen reduction technology (PRT) for Platelet concentrates (PCs). While the …

Improving the bacteriological safety of platelet transfusions

MA Blajchman, M Goldman, F Baeza - Transfusion medicine reviews, 2004 - Elsevier
Despite the increased application of aseptic techniques for blood collection and the
preparation of platelet concentrates, morbidity and mortality arising from the transfusion of …

Revisiting study design and methodology for pathogen reduced platelet transfusions: a round table discussion

NM Heddle, M Cardoso, PF van der Meer - Transfusion, 2020 - Wiley Online Library
Pathogen inactivation/reduction technologies for platelet components have been developed
to enhance microbial safety, and many studies have been carried out to determine whether …

Addressing the risk of bacterial contamination in platelets: a hospital economic perspective

JW Li, ME Brecher, JL Jacobson, SK Harm… - …, 2017 - Wiley Online Library
BACKGROUND Bacterially contaminated platelets (PLTs) remain a serious risk. The Food
and Drug Administration has issued draft guidance recommending hospitals implement …

Current debate on pathogen inactivation of platelet concentrates–To use or not to use?

T Hervig, J Seghatchian, TO Apelseth - Transfusion and Apheresis Science, 2010 - Elsevier
It is an important goal in transfusion practice to improve the quality and safety of platelet
transfusions. Accordingly, blood services have implemented several complimentary …

[HTML][HTML] Bacterial contamination of platelets for transfusion: strategies for prevention

JH Levy, MD Neal, JH Herman - Critical Care, 2018 - Springer
Platelet transfusions carry greater risks of infection, sepsis, and death than any other blood
product, owing primarily to bacterial contamination. Many patients may be at particular risk …

Pathogen reduction technologies: the pros and cons for platelet transfusion

A Magron, J Laugier, P Provost, E Boilard - Platelets, 2018 - Taylor & Francis
The transfusion of platelets is essential for diverse pathological conditions associated with
thrombocytopenia or platelet disorders. To maintain optimal platelet quality and functions …

[CITATION][C] More than one way to enhance bacterial detection in platelet components

H Kamel, M Goldman - Transfusion, 2018 - Wiley Online Library
At the dawn of the 21st century, a call was made for the blood collection community to
immediately initiate a program for detecting the presence of bacteria in units of platelets …

Bacterial contamination of platelet components: prevalence and measures to prevent transfusion-transmitted bacterial infection

L Corash - Progress and Challenges in Transfusion Medicine …, 2008 - karger.com
Bacterial contamination of platelet components represents the most prevalent transfusion-
transmitted infectious risk, with the exception of viral epidemics. Transfusion services have …