HbA1c does not always estimate average glucose

KJ Behan, J Merschen - Clinical Laboratory Science, 2011 - ircommons.uwf.edu
Hemoglobin A1c (HbA1c) testing can be inaccurate in persons with elevated amounts of
Hemoglobin F, or with abnormal hemoglobins found in sickle cell trait, HbC trait and HbE …

Effect of hemoglobinopathies on hemoglobin A1c measurements

CL Malekiani, A Ganesan, CF Decker - The American journal of …, 2008 - amjmed.com
The measurement of glycosolated hemoglobin (HbA1c) is accepted widely as the
cornerstone of the management of diabetes. Recently, a new information campaign and …

Identification of the presence of variant hemoglobin using a measurement of the labile HbA1c (# C) fraction

M Koga, S Inada, A Miyazaki - Annals of Clinical & Laboratory …, 2016 - Assoc Clin Scientists
Labile HbA1c migrates in the# C fraction together with modified hemoglobin (such as
carbamylated hemoglobin, acetaldehyde hemoglobin, and acetylated hemoglobin) when …

Effects of hemoglobin variants on hemoglobin a1c values measured using a high-performance liquid chromatography method

M Lorenzo-Medina, S De-La-Iglesia… - Journal of diabetes …, 2014 - journals.sagepub.com
Background: Hemoglobin A1c (HbA1c) is routinely used to monitor long-term glycemic
control and for diagnosing diabetes mellitus. However, hemoglobin (Hb) gene …

Falsely low HbA1c value due to a rare variant of hemoglobin J-Baltimore

O Barakat, STM Krishnan, K Dhatariya - primary care diabetes, 2008 - Elsevier
HbA1c values are heavily relied on to assess glycemic control. Hemoglobin variants may
interfere with measurements of HbA1c resulting in falsely low values. We present the first …

Effects of hemoglobin C and S traits on the results of 14 commercial glycated hemoglobin assays

SK Mongia, RR Little, CL Rohlfing… - American journal of …, 2008 - academic.oup.com
Glycated hemoglobin is widely used in the management of diabetes mellitus. At least
300,000 Americans with diabetes mellitus have the hemoglobin (Hb) C or S trait. The …

Degree of discrepancy between HbA1c and glycemia in variant hemoglobin is smaller when HbA1c is measured by new-type Arkray HPLC compared with old-type …

M Koga, S Kurebayashi, J Murai, H Saito… - Clinical Biochemistry, 2014 - Elsevier
Objectives Although variant hemoglobin mainly demonstrates inappropriate HbA1c values
measured by high-performance liquid chromatography (HPLC), these values differ …

A mistaken diagnosis of type 2 diabetes due to hemoglobin N-Baltimore

EA Nyenwe, JN Fisher - The American journal of the medical sciences, 2008 - Elsevier
Glycohemoglobin (HbA1c) estimation is the gold standard for assessing long-term glycemic
control in diabetic patients. Some hemoglobin variants interfere with HbA1c assay, thus …

[HTML][HTML] Management of hemoglobin variants detected incidentally in HbA1c testing: a common problem currently lacking a standard approach

MR Lewis, RC Macauley, PR Sheehan, MA Staten… - Diabetes …, 2017 - ncbi.nlm.nih.gov
Although HbA1c is widely used for diagnosis and management of diabetes in clinical
practice and research studies, management of the incidental detection of hemoglobin …

[HTML][HTML] Effects of hemoglobin C, D, E, and S traits on measurements of HbA1c by six methods

CN Lin, TJ Emery, RR Little, SE Hanson… - Clinica chimica acta; …, 2012 - ncbi.nlm.nih.gov
Glycated hemoglobin is hemoglobin that has been irreversibly modified by addition of
glucose through a non-enzymatic process and provides a weighted average of plasma …