Congenital conditions like Down syndrome have been associated with increased risk for
clonal disorders that affect megakaryocytic lineage. The World Health Organization has …

Children with Down syndrome (DS, OMIM# 190685) have an increased risk for a
hematopoietic malignancy. Down syndrome-associated AML (DS-AML) is diagnosed in …

Acute myeloid leukemia (AML) accounts for approximately 20% of childhood leukemia, yet is
responsible for a majority of the deaths from leukemia. Children present with a wide range of …

Acute myeloid leukemia (AML) accounts for approximately 20% of childhood leukemia, yet is
responsible for a majority of the deaths from leukemia. Children present with a wide range of …

Myeloid leukemia of Down syndrome (ML-DS) in young children is associated with distinct
clinical and biological features and is typically initiated with oncogenic mutations in the X …

Context.—Detailed diagnostic features of acute myeloid leukemia in Down syndrome are
lacking, leading to potential misdiagnoses as standard acute myeloid leukemia occurring in …

Children with Down syndrome (DS) have a 10‐to 20‐fold increased risk of developing acute
leukemia. An estimated 10% of newborns with DS develop Transient Myeloproliferative …

Children with Down syndrome (DS) have a markedly increased risk of leukemia. They are at
particular risk of acute megakaryoblastic leukemia, known as myeloid leukemia associated …

Background: Infants with Down syndrome are more prone to transient abnormal
myelopoiesis. A small percentage of this condition can be fatal, yet they are more prone to …

One of the challenges faced in treating children with Down syndrome and leukemia is
balancing curative therapy against potential toxicities. As first reported by the Pediatric …