Switch from Signal Amplification to COBAS® AmpliPrep/COBAS® TaqMan 48: Is There a Need to Re-Baseline?

M Choudhary, G Caldito… - American Society for …, 2015 - clsjournal.ascls.org
Background: Accurate quantitation of plasma Human immunodeficiency virus-1 (HIV) RNA
levels is required for clinical management of HIV-1-infected patients. Several assays are …

Ability of Two Commercially Available Assays (Abbott RealTime HIV-1 and Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 Version 2.0) To Quantify Low HIV-1 RNA …

A Amendola, P Marsella, M Bloisi… - Journal of clinical …, 2014 - Am Soc Microbiol
Concordance between molecular assays may be suboptimal at low HIV-1 viremia levels (<
1,000 copies/ml); therefore, it may be difficult to define and compare virologic endpoints for …

Large-scale comparison of Roche Cobas AmpliPrep/Cobas TaqMan and Abbott RealTime HIV assays

MT Pyne, A Wilson, DR Hillyard - Journal of virological methods, 2012 - Elsevier
Significant underquantitation of HIV RNA has been reported with the Roche Cobas
AmpliPrep/Cobas TaqMan HIV Test (Version 1) compared to other assays. However, these …

Upgraded Cobas Ampliprep-Cobas TaqMan version 2.0 HIV-1 RNA quantification assay versus first version: correction of underestimations

M Wirden, R Tubiana, S Fourati… - Journal of clinical …, 2011 - Am Soc Microbiol
The large underestimations of HIV RNA quantification observed in 17 patients with the first
version of Cobas TaqMan assay have been successfully corrected in the upgraded version …

Fully automated quantification of human immunodeficiency virus (HIV) type 1 RNA in human plasma by the COBAS® AmpliPrep/COBAS® TaqMan® system

W Schumacher, E Frick, M Kauselmann… - Journal of Clinical …, 2007 - Elsevier
BACKGROUND: HIV-1 RNA is a key parameter for reliable diagnosis and treatment of HIV-1
infection. The determination of HIV-1 RNA reduces the pre-seroconversion period in the …

[PDF][PDF] Impact of the COBAS AmpliPrep/COBAS

P Mandrekar, JDC Yao - Citeseer
The COBAS AmpliPrep/COBAS AMPLICOR HIV-1 MONITOR Test, version 1.5 (CAP/CA),
and the COBAS AMPLICOR HIV-1 MONITOR Test, version 1.5, were compared. CAP/CA …

Comparison of the Abbott realtime human immunodeficiency virus type 1 (HIV-1) assay to the Cobas AmpliPrep/Cobas TaqMan HIV-1 test: workflow, reliability, and …

CR Sloma, JJ Germer, TM Gerads… - Journal of clinical …, 2009 - Am Soc Microbiol
ABSTRACT The Abbott RealTime human immunodeficiency virus type 1 (HIV-1) assay
(ART) and the Cobas AmpliPrep/Cobas TaqMan HIV-1 test (CTM) are commercially …

Evaluation of the COBAS ampliprep/COBAS TaqMan system for quantification of human immunodeficiency virus type 1 (HIV-1) RNA by real-time PCR

K Teruya, S Oka, K Fukutake, K Amano… - … zasshi. The Journal …, 2008 - europepmc.org
Background Viral load quantification is standard for monitoring HIV-1 therapy and is crucial
in deciding whether to switch or to continue a current antiretroviral regimen. In Japan, serum …

[HTML][HTML] Estimation of measurement error in plasma HIV-1 RNA assays near their limit of quantification

VD Lima, L Wang, C Brumme, L Wu, JSG Montaner… - Plos one, 2017 - journals.plos.org
Background Plasma HIV-1 RNA levels (pVLs), routinely used for clinical management, are
influenced by measurement error (ME) due to physiologic and assay variation. Objective To …

Concordance of HIV-1 RNA values by amplicor and TaqMan 2.0 in patients with confirmed suppression in clinical trials

W Garner, K White, J Szwarcberg… - Clinical Infectious …, 2016 - academic.oup.com
Abstract Background. The COBAS AMPLICOR HIV-1 MONITOR Test, version 1.5 (Amplicor)
has been replaced with the COBAS AmpliPrep/COBAS TaqMan HIV-1 Test, version 2.0 …