The objective of this study was to develop a simple, cost-effective method of HbF
determination potentially useable in underdeveloped countries to determine sickle cell …

Sickle cell anemia is one of the most commonly inherited diseases, annually affecting
approximately 275,000 births worldwide. The disease is most prevalent in African countries …

The objective of this study was to develop a diagnostic testing method to detect HbS,
distinguish sickle cell homozygotes from heterozygotes, and overcome testing barriers …

In the sickle cell syndromes, Hb A2 measurements aid in the differential diagnosis of sickle
cell anemia from sickle-beta-thalassemia. The purpose of this study is to assess the Hb A2 …

Quantification of sickle hemoglobin (HbS) in patients with sickle cell disease (SCD)
undergoing hydroxyurea or chronic transfusion therapy is essential to monitoring the …

Introduction: Sickle cell disease (SCD) is a common inherited blood disorder caused by
sickle hemoglobin (HbS) which, unlike normal adult hemoglobin (HbA), becomes insoluble …

Abstract Introduction: Fetal hemoglobin (HbF) expression is a major modulator of sickle cell
disease (SCD) severity. Hydroxyurea improves SCD clinical manifestations in part through …

Aim: Sickle cell trait and Hb D-Los Angeles (β121Glu→ Gln) variant have complete blood
count (CBC) and chromatographic similarities. Therefore, the differential diagnosis of these …

Sickle cell disease (SCD) is a common and life-threatening inherited disorder of
hemoglobin, affecting over 400,000 newborns annually. The majority of these births occur in …

Abstract In sub-Saharan Africa, nearly a quarter of a million babies are born with sickle cell
disease (SCD) each year. An estimated 50-90% of these babies die before age 5 due to lack …