Chronic myelocytic leukemia–Part I: History, clinical presentation, and molecular biology

TR Randolph - American Society for Clinical Laboratory Science, 2005 - clsjournal.ascls.org
DATA SOURCES: Current literature. DATA SYNTHESIS: Chronic myelocytic leukemia
(CML) was initially described in 1845 and is considered one of the first leukemias to be …

Biology of chronic myelogenous leukemia

CM Verfaillie - Hematology/oncology clinics of North America, 1998 - Elsevier
Chronic myelogenous leukemia (CML) is a malignant disease of the human hematopoietic
stem cell. The disease is characterized by an abnormal expansion of granulocytic …

The molecular biology of chronic myeloid leukemia

MWN Deininger, JM Goldman… - Blood, The Journal of the …, 2000 - ashpublications.org
Chronic myeloid leukemia (CML) is probably the most extensively studied human
malignancy. The discovery of the Philadelphia (Ph) chromosome in 19601 as the first …

Chronic myelogenous leukemia: molecular diagnostic considerations

JS McClure, CE Litz - Human pathology, 1994 - Elsevier
Chronic myelogenous leukemia (CML) is associated in 95% of cases with the Philadelphia
chromosome (Ph 1) by cytogenetic analysis. This acquired karyotypic abnormality is the …

Chronic myelogenous leukemia: update on biology and treatment.

S Faderl, HM Kantarjian, M Talpaz - Oncology (Williston Park, NY), 1999 - europepmc.org
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder that follows a
characteristic clinical course in which a chronic phase of variable duration precedes an …

Chronic myelogenous leukemia: molecular and cellular aspects

G Pasternak, A Hochhaus, B Schultheis… - Journal of cancer …, 1998 - Springer
Chronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of
the bone marrow and is characterized by greatly increased numbers of granulocytes in the …

Chronic myeloid leukemia

BJ Druker - 2001 - books.google.com
Chronic myeloid leukemia (CML) was the first hematological malignancy to be associated
with a specific chromosome abnormality. This abnormality, known as the Philadelphia …

Chronic myeloid leukemia: cytogenetic methods and applications for diagnosis and treatment

CM Morris - Cancer Cytogenetics: Methods and Protocols, 2011 - Springer
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disease caused by
recombination between the BCR gene on chromosome 22 and the ABL1 gene on …

Chronic myeloid leukemia: Relevance of cytogenetic and molecular assays

A Bennour, A Saad, H Sennana - Critical reviews in oncology/hematology, 2016 - Elsevier
Chronic myeloid leukemia (CML) is the prototype cytogenetic malignancy. Even before the
development of basic G-and R-banding techniques, CML was found to be associated with a …

CML: mechanisms of disease initiation and progression

M Wetzler, M Talpaz, Z Estrov, R Kurzrock - Leukemia & lymphoma, 1993 - Taylor & Francis
Chronic myelogenous leukemia (CML) is a hematological stem cell disorder characterized
by excessive proliferation of the myeloid lineage. It has a progressive course typified by the …