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Research ArticleResearch and Reports

Diagnostic Challenges in Amyloid Light-Chain Amyloidosis

Sam Mosley and Kate Moreau
American Society for Clinical Laboratory Science August 2026, DOI: https://doi.org/10.29074/ascls.2026003334
Sam Mosley
Department of Biomedical and Health Sciences, University of Vermont
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  • For correspondence: smosley{at}uvm.edu
Kate Moreau
Department of Biomedical and Health Sciences, University of Vermont
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Article Information

DOI 
https://doi.org/10.29074/ascls.2026003334

Published By 
American Society for Clinical Laboratory Science
Print ISSN 
0894-959X
Online ISSN 
1945-3574
History 
  • Accepted July 3, 2026
  • Published online August 28, 2026.

Copyright & Usage 
© 2026 © 2026 The American Society for Clinical Laboratory Science American Society for Clinical Laboratory Science

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American Society for Clinical Laboratory Science: 38 (1)
American Society for Clinical Laboratory Science
Vol. 38, Issue 1
1 Jan 2025
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Diagnostic Challenges in Amyloid Light-Chain Amyloidosis
Sam Mosley, Kate Moreau
American Society for Clinical Laboratory Science Aug 2026, DOI: 10.29074/ascls.2026003334

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Diagnostic Challenges in Amyloid Light-Chain Amyloidosis
Sam Mosley, Kate Moreau
American Society for Clinical Laboratory Science Aug 2026, DOI: 10.29074/ascls.2026003334
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  • Article
    • ABSTRACT
    • INTRODUCTION
    • SOCIOECONOMIC BARRIERS
    • HEALTH CARE SYSTEM BARRIERS
    • CLINICAL BARRIERS
    • THE ROLE OF THE LABORATORY
    • REFERENCE INTERVALS AND RENAL CONFOUNDING
    • CONCLUSIONS
    • REFERENCES
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Keywords

  • AI - artificial intelligence
  • AL - amyloid light chain
  • ATTR-CM - transthyretin amyloid cardiomyopathy
  • dFLC - difference between involved and uninvolved light chains
  • eGFR - estimated glomerular filtration rate
  • EHR - electronic health record
  • FLC - free light chain
  • MDT - multidisciplinary team
  • MGUS - monoclonal gammopathy of undetermined significance
  • SES - socioeconomic status
  • VistA - Veterans Health Information Systems and Technology Architecture
  • hematology
  • immunoglobulin light chains
  • immunoglobulin light-chain amyloidosis
  • delayed diagnosis

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