PT  - JOURNAL ARTICLE
AU  - Newkirk, Catherine E.
TI  - Heparin-Induced Thrombocytopenia (HIT): A Case Study
AID  - 10.29074/ascls.23.1.5
DP  - 2010 Jan 01
TA  - American Society for Clinical Laboratory Science
PG  - 5--11
VI  - 23
IP  - 1
4099  - http://hwmaint.clsjournal.ascls.org/content/23/1/5.short
4100  - http://hwmaint.clsjournal.ascls.org/content/23/1/5.full
SO  - Clin Lab Sci2010 Jan 01; 23
AB  - Heparin-induced thrombocytopenia (HIT) ranges from an asymptomatic reaction to heparin with a transient mild thrombocytopenia (HIT I) to a life- and limb-threatening immunological reaction, heparin-induced thrombocytopenia with thrombosis (HITT or HIT II). HITT can occur in patients with any heparin exposure and must be recognized and treated quickly and appropriately to prevent symptomatic and/or fatal thrombosis. HIT will be discussed using a case study approach.ABBREVIATIONS: APTT = activated partial thromboplastin time; AT = anti-thrombin; 14C = carbon-14; CT = computerized topography; DTI = direct thrombin inhibitor; Fc = fragment crystallizable; FDA = Food and Drug Administration; HIPA = heparin-induced platelet aggregation; HIT = heparin-induced thrombocytopenia; HITT = heparin-induced thrombocytopenia with thrombosis; IgG = immunoglobulin G; INR = international normalized ratio; IU/ml = international units per milliliter; IV = intravenous; LMWH = low-molecular-weight heparin; PF4 = platelet factor 4; RBC = red blood cell; SC = subcutaneous; SRA = serotonin release assay; UFH = unfractionated heparin.