PT  - JOURNAL ARTICLE
AU  - Mistler, James March
TI  - A New Testing Algorithm for the Diagnosis of Celiac Disease
AID  - 10.29074/ascls.28.4.212
DP  - 2015 Oct 01
TA  - American Society for Clinical Laboratory Science
PG  - 212--217
VI  - 28
IP  - 4
4099  - http://hwmaint.clsjournal.ascls.org/content/28/4/212.short
4100  - http://hwmaint.clsjournal.ascls.org/content/28/4/212.full
SO  - Clin Lab Sci2015 Oct 01; 28
AB  - The clinical investigation of patients with potential Celiac disease currently encompasses a large differential diagnosis including food allergies, medications, bacterial, viral and parasitic infection, AIDS, and Crohn's disease. The large diagnostic selection, coupled with a vast array of serological markers as well the self-treatment of patients makes diagnosing Celiac disease difficult. A newer marker, anti-deamidated gliadin peptide, should be paired with both the total serum IgA and anti-tissue transglutaminase IgA and IgG for screening symptomatic patients on a gluten diet for best diagnosis. Those patients that test positive by deamidated gliadin peptide and/or anti-tissue transglutaminase should then be confirmed with HLA typing and/or biopsy and started on a gluten-free diet sooner, reducing the destructive effects gluten can do on the intestine.ABBREVIATIONS: CD - celiac disease, GFD - gluten free diet, AGA - anti-gliadin antibodies, TTG - anti-tissue transglutaminase antibodies, EMA - anti-endomysial antibodies, ARA - anti-reticulin antibodies, DGP - anti-deamidated gliadin peptide antibodies, IEL - intraepithelial lymphocytes, GALT - gut-associated lymphoid tissue, EATL - enteropathy-associated T-cell lymphoma.