RT Journal Article
SR Electronic
T1 A New Testing Algorithm for the Diagnosis of Celiac Disease
JF American Society for Clinical Laboratory Science
JO Clin Lab Sci
FD American Society of Chemistry and Laboratory Science
SP 212
OP 217
DO 10.29074/ascls.28.4.212
VO 28
IS 4
A1 Mistler, James March
YR 2015
UL http://hwmaint.clsjournal.ascls.org/content/28/4/212.abstract
AB The clinical investigation of patients with potential Celiac disease currently encompasses a large differential diagnosis including food allergies, medications, bacterial, viral and parasitic infection, AIDS, and Crohn's disease. The large diagnostic selection, coupled with a vast array of serological markers as well the self-treatment of patients makes diagnosing Celiac disease difficult. A newer marker, anti-deamidated gliadin peptide, should be paired with both the total serum IgA and anti-tissue transglutaminase IgA and IgG for screening symptomatic patients on a gluten diet for best diagnosis. Those patients that test positive by deamidated gliadin peptide and/or anti-tissue transglutaminase should then be confirmed with HLA typing and/or biopsy and started on a gluten-free diet sooner, reducing the destructive effects gluten can do on the intestine.ABBREVIATIONS: CD - celiac disease, GFD - gluten free diet, AGA - anti-gliadin antibodies, TTG - anti-tissue transglutaminase antibodies, EMA - anti-endomysial antibodies, ARA - anti-reticulin antibodies, DGP - anti-deamidated gliadin peptide antibodies, IEL - intraepithelial lymphocytes, GALT - gut-associated lymphoid tissue, EATL - enteropathy-associated T-cell lymphoma.