RT Journal Article
SR Electronic
T1 Anti-hormones: Mechanism and Use in Treatment of Breast Cancer
JF American Society for Clinical Laboratory Science
JO Clin Lab Sci
FD American Society of Chemistry and Laboratory Science
SP 45
OP 49
DO 10.29074/ascls.25.1.45
VO 25
IS 1
A1 Dinda, Sumi
YR 2012
UL http://hwmaint.clsjournal.ascls.org/content/25/1/45.abstract
AB Define the roles of estrogen and progesterone in breast and uterine cells.Define hormone-dependent and independent tumors.Describe the classification and main functions of anti-hormone therapy.Explain the mechanism of aromatase inhibitors, ERDs and SERMs.Explain the differences between the mechanisms of tamoxifen and raloxifene.Breast cancer is the second-leading cause of cancer-related death in women. Recently, new drugs are being developed based on the molecular mechanisms of receptors, tumor suppressor genes, monoclonal antibodies, tumor markers and anti-hormone therapy. Anti-hormone therapy is used in the treatment of hormone-dependent breast tumors. Among the anti-hormone therapies, a substantial amount of research has been focused on the development of the ideal selective estrogen receptor modulator to treat metastatic breast tumors and to prevent breast cancer in high risk women.