PT  - JOURNAL ARTICLE
AU  - Wells, Rebecca S
AU  - Fisher, Dennis G
AU  - Fenaughty, Andrea M
AU  - Cagle, Henry H
AU  - Jaffe, Adi
TI  - Hepatitis A Prevalence among Injection Drug Users
AID  - 10.29074/ascls.19.1.12
DP  - 2006 Jan 01
TA  - American Society for Clinical Laboratory Science
PG  - 12--17
VI  - 19
IP  - 1
4099  - http://hwmaint.clsjournal.ascls.org/content/19/1/12.short
4100  - http://hwmaint.clsjournal.ascls.org/content/19/1/12.full
SO  - Clin Lab Sci2006 Jan 01; 19
AB  - OBJECTIVE: The purpose of this study was to develop a descriptive model of the association between injection drug use and hepatitis A (HAV) in a sample of injection drug users (IDUs).DESIGN: From May 1997 to July 1999, 493 subjects were administered the NIDA Risk Behavior Assessment (RBA). Participants had blood drawn; sera were tested for antibodies to HAV, hepatitis B core (HBcAB), and hepatitis C. The principal method of analysis was logistic regression.SETTING: The study took place in a community-based field station in Anchorage, Alaska.PARTICIPANTS: Eligibility was determined using the following criteria: a) age greater than 17 years, b) possession of picture identification, c) positive urinalysis for cocaine metabolites, morphine, and/or amphetamines using the ONTRAK® system (Roche Diagnostics), and d) injection drug use in the last six months as confirmed by presentation of track marks.MAIN OUTCOME MEASURE: Presence of antibodies to HAV infection.RESULTS: The prevalence of total HAV antibody in our sample was 33% (161/493). The final multivariate logistic model, using positive HAV serostatus as the outcome, included positive HBcAB serostatus (OR = 3.43; 95% CI, 2.22-5.30), less than high school education (vs. high school or greater education) (OR = 2.05; 95% CI, 1.33-3.17), age (OR = 1.06 (each year); 95% CI, 1.03-1.09), number of days injected heroin in the last 30 days (OR = 1.05 (each day), 95% CI, 1.01-1.08), and race (White vs. all other race/ethnicities) (OR = 0.49; 95% CI, 0.32-0.75).CONCLUSIONS: A model including both demographic and drug use variables best describes HAV prevalence in this sample. Findings suggest that IDUs are targets for interventions focusing on hepatitis vaccinations and hygiene practices. Further research is needed to understand the association of HAV with hepatitis B infection.ABBREVIATIONS USED: CI = confidence interval; HAV = hepatitis A; HBV = hepatitis B; HCV = hepatitis C; HIV = human immunodeficiency virus; IDUs = injection drug users; M = mean; OR = odds ratio; RBA = risk behavior assessment.