PT  - JOURNAL ARTICLE
AU  - Edwards, Brandon
AU  - Washington, Irsha
AU  - Pretlow, Lester G.
AU  - Passmore, Gregory
AU  - Dias, James
AU  - Wise, Scott
TI  - Sequential Assessment of Troponin in the Diagnosis of Myocardial Infarction
AID  - 10.29074/ascls.26.2.95
DP  - 2013 Apr 01
TA  - American Society for Clinical Laboratory Science
PG  - 95--99
VI  - 26
IP  - 2
4099  - http://hwmaint.clsjournal.ascls.org/content/26/2/95.short
4100  - http://hwmaint.clsjournal.ascls.org/content/26/2/95.full
SO  - Clin Lab Sci2013 Apr 01; 26
AB  - According to the American Heart Association, cardiovascular disease accounts for more than one third of all deaths in the United States. 1 The purpose of this retrospective case-control study was to determine which sample taken in a sequential draw was most important in diagnosing an acute myocardial infarction (AMI). One-hundred subjects were selected from a convenience sample. The “risk” of AMI diagnosis was modeled using binary multiple logistic regression. Overall, 78% (39 out of 50 cases) were diagnosed with an AMI at Tinitial. Clearly, the initial cTnI assay is the most critical of the four sequential time points for the accurate assessment of the presence or absence of an AMI. Most importantly, sequential troponin testing increased the ability to diagnose AMI by 10-fold.ABBREVIATIONS: ECG - electrocardio-gram, CK - creatine kinase, AMI – acute myocardial infarction, cTnI - cardiac troponin I, CSRA - Central Savannah River Area, STEMI - ST-elevation myocardial infarction