RT Journal Article
SR Electronic
T1 “It Was the Best of Times, It was The Worst of Times”: Cardiovascular Disease and Troponins
JF American Society for Clinical Laboratory Science
JO Clin Lab Sci
FD American Society of Chemistry and Laboratory Science
SP ascls.118.000661
DO 10.29074/ascls.118.000661
A1 Chiasera, Janelle M
A1 Giordano, Samantha
A1 Xavier, Neena
A1 Oliveira, Ana
A1 Estes, Robert
A1 George, Remo
A1 Gilford, Tosi
A1 Glasgow, Krystle
A1 Hallman, Heather
A1 Josephat, Floyd
A1 Li, Wei
YR 2018
UL http://hwmaint.clsjournal.ascls.org/content/early/2018/11/09/ascls.118.000661.abstract
AB There have been significant changes in the diagnosis and definition of acute myocardial infarction over the years. From its first description and definition over 150 years ago to the high sensitivity cardiac troponin assays of today, we have come a long way in the diagnosis, management, and treatment of those with cardiovascular disease. With the recent Food and Drug Administration’s (FDA) clearance of a fifth generation high-sensitivity cardiac troponin assay, a new history in diagnosing, treatment and managing those with heart disease is just beginning. The three articles associated with this focus series describe advances in diagnosis and definition of acute myocardial infarction (AMI) with a specific focus on troponins. The first article presents an in-depth description into the structure and function of troponin in health and disease. The second article presents a description of myocardial infarction (MI), how the diagnosis and definition of MI has changed over the years and ends with a description of the high sensitive troponin assays. The third article presents clinical implications of the new high sensitivity troponin assays.