PT  - JOURNAL ARTICLE
AU  - Larry J Smith
AU  - Donna D Castellone
AU  - Michael A Nardi
TI  - Hemophilia: Where are we today?
AID  - 10.29074/ascls.118.001271
DP  - 2019 Jan 01
TA  - American Society for Clinical Laboratory Science
PG  - ascls.118.001271
4099  - http://hwmaint.clsjournal.ascls.org/content/early/2019/03/28/ascls.118.001271.short
4100  - http://hwmaint.clsjournal.ascls.org/content/early/2019/03/28/ascls.118.001271.full
AB  - Hemophilia is a rare congenital bleeding disorder characterized by decreased levels of coagulation factor VIII or factor IX in the circulation. The disorder is associated with lifelong bleeding that ranges from mild to severe in affected individuals. Treatment requires replacement of the missing factor and is often associated with the development of antibodies that may exacerbate the bleeding diathesis seen in these individuals. The clinical laboratory plays a unique role in the diagnosis of hemophilia and in monitoring the effectiveness of standard replacement therapy, as well as many of the newer replacement therapies that have been developed.