RT Journal Article
SR Electronic
T1 Hemophilia: Where are we today?
JF American Society for Clinical Laboratory Science
JO Clin Lab Sci
FD American Society of Chemistry and Laboratory Science
SP ascls.118.001271
DO 10.29074/ascls.118.001271
A1 Larry J Smith
A1 Donna D Castellone
A1 Michael A Nardi
YR 2019
UL http://hwmaint.clsjournal.ascls.org/content/early/2019/03/28/ascls.118.001271.abstract
AB Hemophilia is a rare congenital bleeding disorder characterized by decreased levels of coagulation factor VIII or factor IX in the circulation. The disorder is associated with lifelong bleeding that ranges from mild to severe in affected individuals. Treatment requires replacement of the missing factor and is often associated with the development of antibodies that may exacerbate the bleeding diathesis seen in these individuals. The clinical laboratory plays a unique role in the diagnosis of hemophilia and in monitoring the effectiveness of standard replacement therapy, as well as many of the newer replacement therapies that have been developed.