RT Journal Article
SR Electronic
T1 The Generation and Applications of Biological Variation Data in Laboratory Medicine
JF American Society for Clinical Laboratory Science
JO Clin Lab Sci
FD American Society of Chemistry and Laboratory Science
SP 37
OP 42
DO 10.29074/ascls.2018000323
VO 31
IS 1
A1 Vasani, Niketa M.
A1 Patel, Biren D.
A1 Rai, Alex
A1 Mehta, Shashi
YR 2018
UL http://hwmaint.clsjournal.ascls.org/content/31/1/37.abstract
AB In recent years, increasing consideration has been given to the study of biological variation on laboratory analytes. Data on biological variation have a number of applications in the laboratory, including setting the quality specifications for analytical performance, assessing the usefulness of population-based reference ranges, assessing variation in serial results from an individual, and determining the optimal sample for analyzing a specific constituent. Thus, it is essential to generate accurate and reliable data on biological variation using a standardized study protocol. Currently, there are guidelines available to enable the standardized production of biological variation data. Here, we aim to provide recommendations on preferred experimental procedures and statistical methods for producing correct biological variation data in accordance with published guidelines.