PT  - JOURNAL ARTICLE
AU  - Chiasera, Janelle M.
AU  - Giordano, Samantha
AU  - Xavier, Neena
AU  - Oliveira, Ana
AU  - Estes, Robert
AU  - George, Remo
AU  - Gilford, Tosi
AU  - Glasgow, Krystle
AU  - Hallman, Heather
AU  - Josephat, Floyd
AU  - Li, Wei
TI  - “It Was the Best of Times, It Was the Worst of Times”: Cardiovascular Disease and Troponins
AID  - 10.29074/ascls.2018000661
DP  - 2018 Oct 01
TA  - American Society for Clinical Laboratory Science
PG  - 190--191
VI  - 31
IP  - 4
4099  - http://hwmaint.clsjournal.ascls.org/content/31/4/190.short
4100  - http://hwmaint.clsjournal.ascls.org/content/31/4/190.full
SO  - Clin Lab Sci2018 Oct 01; 31
AB  - There have been significant changes in the diagnosis and definition of acute myocardial infarction over the years. From its first description and definition over 150 years ago to the high-sensitivity cardiac troponin assays of today, we have come a long way in the diagnosis, management, and treatment of those with cardiovascular disease. With the recent United States Food and Drug Administration’s clearance of the fifth-generation high-sensitivity cardiac troponin assays, a new history in diagnosing, treating, and managing those with heart disease is just beginning. The three articles associated with this FOCUS series described advances in diagnosis and definition of acute myocardial infarction (AMI), with the first article presenting an in-depth description into the structure and function of troponin in health and disease, a second article presenting a description of AMI and how its diagnosis and definition has changed over the years culminating with a description of the highly sensitive troponin assays, and a third article presenting clinical implications of the new high-sensitivity troponin assays.