PT - JOURNAL ARTICLE AU - Castellone, Donna D. TI - Past, Present, and Future Options in the Treatment of Hemophilia A AID - 10.29074/ascls.2018001032 DP - 2019 Jan 01 TA - American Society for Clinical Laboratory Science PG - 36--42 VI - 32 IP - 1 4099 - http://hwmaint.clsjournal.ascls.org/content/32/1/36.short 4100 - http://hwmaint.clsjournal.ascls.org/content/32/1/36.full SO - Clin Lab Sci2019 Jan 01; 32 AB - Patients who present with hemophilia A require treatment to replace low levels of factor VIII (FVIII). Intervention can either be on-demand or prophylactic. The goal of therapy is to prevent joint bleeds that lead to permanent damage. The progression of therapy in hemophilia A has provided patients with options that result in a greatly improved quality of life. The newest development of gene therapy, a replacement for FVIII, may be the answer to cure this disorder. This review provides a historical account of the treatment of hemophilia A as well as current available treatment options.