PT  - JOURNAL ARTICLE
AU  - Nardi, Michael A.
TI  - Laboratory Monitoring of Factor VIII and Factor IX in Hemophilia Patients
AID  - 10.29074/ascls.2018001305
DP  - 2019 Jan 01
TA  - American Society for Clinical Laboratory Science
PG  - 27--35
VI  - 32
IP  - 1
4099  - http://hwmaint.clsjournal.ascls.org/content/32/1/27.short
4100  - http://hwmaint.clsjournal.ascls.org/content/32/1/27.full
SO  - Clin Lab Sci2019 Jan 01; 32
AB  - This review describes and discusses the different types of factor assays used in the clinical laboratory for the diagnosis, as well as during therapeutic management, of hemophilia patients. After diagnosis, infusion of factor replacement concentrates is the standard of treatment for patients with hemophilia to prevent or treat bleeding episodes. Monitoring of the factor activity is necessary to assure proper treatment. Several assays are used to assess the factor activity at the time of diagnosis and during therapeutic management. The pros and cons of each assay are discussed in detail. With the introduction of many new replacement products, it is important the clinical laboratory understands the advantages and disadvantages of each assay with respect to each of the replacement products available.