RT Journal Article
SR Electronic
T1 Utility of Immunofixation as a Follow-up to Select Abnormal Serum Protein Electrophoresis Patterns and Suggestions for Clinical Correlation
JF American Society for Clinical Laboratory Science
JO Clin Lab Sci
FD American Society of Chemistry and Laboratory Science
DO 10.29074/ascls.2020003148
A1 Johnson, Curtiss V
A1 Strobel, Stephen
YR 2024
UL http://hwmaint.clsjournal.ascls.org/content/early/2024/09/27/ascls.2020003148.abstract
AB Serum protein electrophoresis (SPE) is a valuable tool for clinical laboratories to identify various protein abnormalities and disease states. Given certain SPE patterns, it is beneficial to know if subsequent immunofixation electrophoresis (IFE) is warranted to detect underlying abnormal bands and whether further clinical correlation is recommended. Using a sample of 160 patients in 1 hospital lab, it was possible to involve both medical technologists and clinical pathologists in identifying abnormal SPE patterns of interest and to craft recommendations for using follow-up IFE to detect clinically significant protein abnormalities. Utilizing a similar process and guidelines of this nature may be beneficial in increasing diagnostic efficiency and efficacy for clinical labs performing electrophoretic testing on patients presenting with such patterns.