Table 2.

Laboratory assays for von Willebrand Disease Diagnosis

Initial assays for VWD

  1. von Willebrand factor antigen (VWF:Ag)

  2. von Willebrand factor activity (VWF:Act)

    1. Ristocetin cofactor activity (VWF:RCo)

    2. Von Willebrand factor immuno-activity (VWF:Lx)

    3. Collagen binding assay (VWF:CBA)

  3. FVIII clotting activity assay (FVIII:C)

Specialized assays for classification of VWD

  1. von Willebrand factor multimers (VWFM)

  2. Ristocetin-induced platelet aggregation (RIPA)