Classification schemes of β-lactamase enzymes. Modified from Bush and Jacoby23
| Ambler Classification | A | B | C | D |
|---|---|---|---|---|
| β-lactamase | Penicillinase | Metallo β-lactamase | Cephalosporinase | Oxacillinase |
| Bush/Jacoby classification* | PC1, TEM, SHV, VEB, PER, PSE,CARB, RTG | IMP, VIM, NDM, IND, L1, CAU, GOB,FEZ | AmpC, ACT, CMY, FOX, MIR, CMY | OXA |
| Common phenotype | Extended-spectrum β-lactamases | Carbapenemases | Extendedspectrum β- lactamases | Carbapenemases |
↵* Bolded enzymes in the Bush/Jacoby column are clinically important.