Factor levels to manage bleeds
Severity of Bleed | Type of Bleed | Desired FVIII Level | *Dosage |
|---|---|---|---|
| Mild hemorrhages | Early hemarthrosis, epistaxis, gingival bleeding | 30 IU | 1–3 doses FVIII |
| Major hemorrhages | Late hemarthrosis, muscle bleeds | 50 IU | Many doses, with continuous monitoring of FVIII levels |
| Life-threatening bleed | Major trauma or operation, advanced or recurrent hemarthrosis, major gastrointestinal bleeding, head trauma, compromise of limb or compartment syndrome | 80–100 IU | Continuous infusions |
*The formula for patient dosage to determine the number of units of FVIII to correct the activity level is as follows: Dose in FVIII IU = (wt in kg) × (desired FVIII increase (IU)) × (0.5 IU/kg per IU/dL).