Table 1.

List of available chromogenic substrate assay kits

Factor VIII Kits
Name	Manufacturer	FDA Status	Detection Limit^c,e
Biophen FVIII:C^a	Hyphen-Biomed	None (RUO)	2%
Coamatic Factor VIII^a	Chromogenix	Approved	0.5%
Coatest SP FVIII^b	Chromogenix	Approved	1%
Coatest SP4 FVIII^b	Chromogenix	Approved	1%
FVIII Chromogenic Assay^b	Siemens Healthcare	Approved	NR
Hemosil Electrachrome FVIII^a	Insturmentation Laboratory	None (RUO)	0.5%
Technoclone FVIII:C^ab	Technoclone	None (RUO)	0%
Factor IX Kits
Name	Manufacturer	FDA Status	Detection Limit
Biophen Factor IX^a	Hyphen-Biomed	None (RUO)	0.5%
ROX Factor IX^a	Rossix	None (RUO)	0.5%

FDA, U.S. Food and Drug Administration; N.R., not reported; RUO, research use only; ^a High range and low range calibration curves suggested; ^b Single calibration curve;^c Value obtained from reagent package insert; ^d Value for low range calibration curve listed.