List of FDA-approved EHL products
| Variant Name | Manufacturer | Year Approved | Half-life |
|---|---|---|---|
| EHL-FVIII Products | |||
| Adynovate (amino-group PEGylation of full-length FVIII) | Shire | 2015 | 14.7 hours |
| Eloctate (Fc-fusion with BDD FVIII) | Bioverativ | 2014 | 19.0 hours |
| EHL-FIX Products | |||
| Alprolix (Fc-FIX fusion) | Bioverativ | 2014 | 82.1 hours |
| Idelvion (Albumin-FIX fusion) | CSL Behring | 2015 | 90.0 hours |
| N9-GP, Rebinyn, Refixia, (GlycoPEGylated-FIX) | Novo-Nordisk | 2017 | 92.7 hours |
EHL, extended half-life; FDA, U.S. Food and Drug Administration; FIX, factor IX; FVIII, factor VIII; N9-GP, glycopegylated rFIX; PEG, polyethylene glycol.