Selected hereditary colorectal cancer
| Selected Hereditary Colorectal Cancer Syndromes | ||
|---|---|---|
| Syndrome | Gene(s) | Mode of Inheritance |
| FAP | APC | Dominant |
| Hereditary nonpolyposis colorectal cancer | MLH1, MSH2, MSH6, PMS2, TACSTD1 | Dominant |
| MYH-polyposis | MUTYH | Recessive |
Discovery of germline mutations in these syndromes has been critical to understanding the molecular mechanisms of CRC. (adapted from Ma et al. (2018) Pathology and genetics of hereditary colorectal cancer)16