Background & Aims The lack of a preclinical model of progressive non-alcoholic steatohepatitis
(NASH) that recapitulates human disease is a barrier to therapeutic development. …

Recently, we demonstrated that ceramide kinase, and its product, ceramide 1-phosphate (Cer-1-P),
were mediators of arachidonic acid released in cells in response to interleukin-1β …

Phosphorylated sphingolipids ceramide-1-phosphate (C1P) and sphingosine-1-phosphate (S1P)
have emerged as key regulators of cell growth, survival, migration and inflammation 1 , …

Background— Right ventricular (RV) dysfunction (RVD) is the most frequent cause of death
in patients with pulmonary arterial hypertension. Although abnormal energy substrate use …

Background Hypertension is, amongst others, characterized by endothelial dysfunction and
vascular remodeling. As sphingolipids have been implicated in both the regulation of …

Glutathione depletion and 12-lipoxygenase-dependent metabolism of arachidonic acid are
known to be implicated in neurodegeneration associated with acute ischemic stroke. The …

OBJECTIVE We sought to determine the effect of intensive blood pressure (BP) control on
cardiovascular outcomes in participants with type 2 diabetes mellitus (T2DM) and additional …

Ceramide kinase (CERK) is a critical mediator of eicosanoid synthesis, and its product,
ceramide-1-phosphate (C1P), is required for the production of prostaglandins in response to …

Diet is major modifiable risk factor for cardiovascular disease that can influence the immune
status of the individual and contribute to persistent low-grade inflammation. In recent years, …

Little is known about the regulation of eicosanoid synthesis proximal to the activation of
cytosolic phospholipase A 2 α (cPLA 2 α), the initial rate-limiting step. The current view is that …