User profiles for Jianzhi Zhang
 | Jianzhi ZhangProfessor of Ecology and Evolutionary Biology, University of Michigan Verified email at umich.edu Cited by 26535 |
Evolution by gene duplication: an update
J Zhang - Trends in ecology & evolution, 2003 - cell.com
The importance of gene duplication in supplying raw genetic material to biological evolution
has been recognized since the 1930s. Recent genomic sequence data provide substantial …
has been recognized since the 1930s. Recent genomic sequence data provide substantial …
Synonymous mutations in representative yeast genes are mostly strongly non-neutral
Synonymous mutations in protein-coding genes do not alter protein sequences and are thus
generally presumed to be neutral or nearly neutral 1 , 2 , 3 , 4 – 5 . Here, to experimentally …
generally presumed to be neutral or nearly neutral 1 , 2 , 3 , 4 – 5 . Here, to experimentally …
Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution
X He, J Zhang - Genetics, 2005 - academic.oup.com
Gene duplication is the primary source of new genes. Duplicate genes that are stably
preserved in genomes usually have divergent functions. The general rules governing the …
preserved in genomes usually have divergent functions. The general rules governing the …
Adaptive diversification of bitter taste receptor genes in mammalian evolution
The diversity and evolution of bitter taste perception in mammals is not well understood.
Recent discoveries of bitter taste receptor (T2R) genes provide an opportunity for a genetic …
Recent discoveries of bitter taste receptor (T2R) genes provide an opportunity for a genetic …
Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular level
Detecting positive Darwinian selection at the DNA sequence level has been a subject of
considerable interest. However, positive selection is difficult to detect because it often operates …
considerable interest. However, positive selection is difficult to detect because it often operates …
Positive Darwinian selection after gene duplication in primate ribonuclease genes
Evolutionary mechanisms of origins of new gene function have been a subject of long-standing
debate. Here we report a convincing case in which positive Darwinian selection …
debate. Here we report a convincing case in which positive Darwinian selection …
[HTML][HTML] Why do hubs tend to be essential in protein networks?
X He, J Zhang - PLoS genetics, 2006 - journals.plos.org
The protein–protein interaction (PPI) network has a small number of highly connected protein
nodes (known as hubs) and many poorly connected nodes. Genome-wide studies show …
nodes (known as hubs) and many poorly connected nodes. Genome-wide studies show …
The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms
It was first noticed 100 years ago that mutations tend to affect more than one phenotypic
characteristic, a phenomenon that was called 'pleiotropy'. Because pleiotropy was found so …
characteristic, a phenomenon that was called 'pleiotropy'. Because pleiotropy was found so …
Gene Sequence-Based Criteria for Identification of New Rickettsia Isolates and Description of Rickettsia heilongjiangensis sp. nov
We propose genetic guidelines for the classification of rickettsial isolates at the genus, group,
and species levels by using sequences of the 16S rRNA (rrs) gene and four protein-coding …
and species levels by using sequences of the 16S rRNA (rrs) gene and four protein-coding …
Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkey
J Zhang, Y Zhang, HF Rosenberg - Nature genetics, 2002 - nature.com
Although the complete genome sequences of over 50 representative species have revealed
the many duplicated genes in all three domains of life 1 , 2 , 3 , 4 , the roles of gene …
the many duplicated genes in all three domains of life 1 , 2 , 3 , 4 , the roles of gene …
