Nucleolar Arf sequesters Mdm2 and activates p53
JD Weber, LJ Taylor, MF Roussel, CJ Sherr… - Nature cell …, 1999 - nature.com
The Ink4/Arf locus encodes two tumour-suppressor proteins, p16 Ink4a and p19 Arf, that
govern the antiproliferative functions of the retinoblastoma and p53 proteins, respectively. Here …
govern the antiproliferative functions of the retinoblastoma and p53 proteins, respectively. Here …
Redox-dependent downregulation of Rho by Rac
AS Nimnual, LJ Taylor, D Bar-Sagi - Nature cell biology, 2003 - nature.com
Rac and Rho GTPases function as critical regulators of actin cytoskeleton remodelling during
cell spreading and migration. Here we demonstrate that Rac-mediated reactive oxygen …
cell spreading and migration. Here we demonstrate that Rac-mediated reactive oxygen …
Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response
…, PO Simon, CK Schmitt, LJ Taylor… - The Journal of …, 2001 - Am Soc Clin Investig
This study investigated whether soluble paracrine factors mediated Salmonella-induced IL-8
expression in polarized model intestinal epithelia. We found that the basolateral media of …
expression in polarized model intestinal epithelia. We found that the basolateral media of …
Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product
AH Cavanaugh, WM Hempel, LJ Taylor, V Rogalsky… - Nature, 1995 - nature.com
THEprotein encoded by the retinoblastoma susceptibility gene (Rb) functions as a tumour
suppressor and negative growth regulator 1 . As actively growing cells require the ongoing …
suppressor and negative growth regulator 1 . As actively growing cells require the ongoing …
Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
HH Jeng, LJ Taylor, D Bar-Sagi - Nature communications, 2012 - nature.com
Mammalian cells contain three closely related ras genes, H-ras, K-ras and N-ras. Although
in a given tumour type, oncogenic mutations are selectively observed in only one of the ras …
in a given tumour type, oncogenic mutations are selectively observed in only one of the ras …
[PDF][PDF] Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination
L Xu, V Lubkov, LJ Taylor, D Bar-Sagi - Current Biology, 2010 - cell.com
Ras proteins play a central role in transducing signals that control cell proliferation,
differentiation, motility, and survival. The location-specific signaling activity of Ras has been …
differentiation, motility, and survival. The location-specific signaling activity of Ras has been …
[PDF][PDF] Spatial regulation of EGFR signaling by Sprouty2
HJ Kim, LJ Taylor, D Bar-Sagi - Current Biology, 2007 - cell.com
Ligand-induced activation of the epidermal growth factor receptor (EGFR) initiates multiple
signal-transduction pathways as well as trafficking events that relocalize the receptors from …
signal-transduction pathways as well as trafficking events that relocalize the receptors from …
Induction of the cellular E2F-1 promoter by the adenovirus E4-6/7 protein
J Schaley, RJ O'Connor, LJ Taylor, D Bar-Sagi… - Journal of …, 2000 - Am Soc Microbiol
The adenovirus type 5 (Ad5) E4-6/7 protein interacts directly with different members of the
E2F family and mediates the cooperative and stable binding of E2F to a unique pair of binding …
E2F family and mediates the cooperative and stable binding of E2F to a unique pair of binding …
Structural Requirements for the Specific Recognition of an m7G mRNA Cap
PC Hsu, MR Hodel, JW Thomas, LJ Taylor… - Biochemistry, 2000 - ACS Publications
7-Methylguanosine (m 7 G), also known as the mRNA “cap”, is used as a molecular tag in
eukaryotic cells to mark the 5‘ end of messenger RNAs. The mRNA cap is required for several …
eukaryotic cells to mark the 5‘ end of messenger RNAs. The mRNA cap is required for several …
Androgen regulation of ribosomal RNA synthesis in LNCaP cells and rat prostate
RL Kabler, A Srinivasan, LJ Taylor, J Mowad… - The Journal of Steroid …, 1996 - Elsevier
Androgen-dependent growth of prostate tissue has been well documented. An additional
prerequisite for cellular growth is the accumulation of ribosomes. It is thus reasonable to …
prerequisite for cellular growth is the accumulation of ribosomes. It is thus reasonable to …