Background: Previous evaluations of HPLC as a tool for detection of hemoglobin variants
have done so within newborn-screening programs and/or by use of stored samples. We …

Patients with HIV-1 immune-related thrombocytopenia (HIV-1–ITP) have a unique Ab against
platelet GPIIIa49-66 capable of inducing oxidative platelet fragmentation in the absence of …

Background: Mechanisms for increased cardiovascular risk in HIV-1-infected adults are
incompletely understood, but platelet activation and immune activation leading to a …

Patients with early HIV-1 infection develop an autoimmune thrombocytopenia in which
antibody is directed against an immunodominant epitope of the β 3 (glycoprotein IIIa [GPIIIa]) …

Thrombocytopenic purpura has recently been noted in sexually active homosexual men. To
elucidate the pathogenesis of thrombocytopenic purpura in this population, we compared …

Some studies suggest that mean platelet volume (MPV) correlates with increased risk for
cardiovascular morbidity and mortality. In this study, we aim to assess reproducibility, need for …

Background: Enhanced platelet activation in human immunodeficiency virus (HIV)‐1‐infected
patients has been reported and shown to strongly correlate with plasma viral load. …

Anti-platelet integrin GPIIIa49-66 antibody (Ab) induces complement-independent platelet
oxidative fragmentation and death by generation of platelet peroxide following NADPH …

Since November 1982 we have seen an association of thrombocytopenic purpura with chronic
narcotic addiction in 70 patients with a mean platelet count of 53 000 ±4000 (SE); 33 had …

Background: Light transmission aggregometry (LTA) is considered the gold standard for
investigating platelet activity ex vivo. However, LTA protocols are not standardized, and …